- Proteolytic enzymes gently resurface to reveal healthy, smooth and polished skin. Clean Zyme Cleanser and Skin Zyme Mask are supplemental home care exfoliation products that have the ability to remove dead skin cells without harming sensitive or irritated tissues. Use anytime for an immediate polished look. Intended to be used as a pair. Both products are also great when used as part of a comprehensive skin care regimen. Key Ingredients: Proteolytic Enzyme - Papain from Green Unripened Papaya. Apply Skin Zyme in a thin even layer over entire face (and neck, if desired) and allow to remain for up to 20 minutes. To remove Skin Zyme, apply a small amount of Clean Zyme to face and massage very gently to achieve emulsification. Remove with a washcloth and splash face 10 to 15 times with lukewarm water. Blot dry and follow with usual Skin Care Management products and/or moisturizer.