- Proteolytic enzymes gently resurface to reveal healthy, smooth and polished skin. Clean Zyme Cleanser and Skin Zyme Mask are supplemental home care exfoliation products that have the ability to remove dead skin cells without harming sensitive or irritated tissues. Use anytime for an immediate polished look. Intended to be used as a pair. Both products are also great when used as part of a comprehensive skin care regimen. Key Ingredients: Proteolytic Enzyme - Papain from Green Unripened Papaya. Clean Zyme should be applied in place of regular cleanser and left on 1 to 2 minutes. Remove with a clean, wet and wrung out washcloth using lukewarm water. Blot dry.