- This dry scalp treatment that effectively promotes healthy looking hair and scalp. The active ingredient, Zinc Pyrithione, helps prevent the itching and flaking associated with dandruff. Anti-Dandruff Shampoo is also an ideal treatment shampoo for use during winter months, in dry climates, or 1-2 times a week for healthy scalp maintenance. Wet hair thoroughly. Massage a small amount into hair and scalp. Rinse well. For best results, use at least twice a week or as directed by a physician.